PKAα/β cat (phospho-T197) polyclonal Antibody | BS4345

PKAα/β cat (phospho-T197) polyclonal Antibody | BS4345 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: PRKACA and PRKACB are members of the Ser/Thr protein kinase family and are a catalytic subunit of cAMP-dependent protein kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-PKAα/β cat (T197) polyclonal Antibody detects endogenous levels of PKAα/βcat protein when phosphorylated at Thr197.

Molecular Weight: ~ 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PRKACA; PKACA; PKA Ca; cAMP-dependent protein kinase catalytic subunit beta; PKA C-beta; PRKACB; PKACB; PKA Cb;

Immunogen: Synthetic phosphopeptide derived from human PKAα around the phosphorylation site of Threonine 197.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phospholipase Signaling,Protein Kinase C Signaling,Inhibition of Apoptosis,G Protein-coupled Receptors Signaling to MAPK Erk,Mitochondrial Control of Apoptosis,