PKC beta 2 Antibody| F40137-0.08ML/F40137-0.4ML

PKC beta 2 Antibody| F40137-0.08ML/F40137-0.4ML | Gentaur UK, US & Europe Distribution

Background: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3' end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse, Primate, Rat

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the PKC beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This PKC beta 2 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 642-673 from the human protein was used as the immunogen for this PKC beta 2 antibody.

Storage: Aliquot the PKC beta 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A