PKCβ polyclonal Antibody | BS91081

PKCβ polyclonal Antibody | BS91081 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC IHC

Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200

Background: Calcium-activated, phospholipid- and diacylglycerol (DAG) -dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity) . Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PKCβ polyclonal Antibody detects endogenous levels of PKCβ protein.

Molecular Weight: 77 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PKC-B, PRKCB, PKC-beta, PKCB, PRKCB1, KPCB, PKC beta, PKC-B, PKC-beta, PKCB, Prkcb, PRKCB I, PRKCB1, PRKCB2, Protein kinase C beta, Protein kinase C beta type, protein kinase C, beta 1 polypeptide, protein kinase C, beta-1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified

Pathway: