PKF118-310 | B3373

PKF118-310 | B3373

Description: PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. It disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM). PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.

Alternate Name/Synonyms: 1,6-dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione Toxoflavin NSC 67078

Appearance: Off-white to light brown Solid

Formulation:

CAS Number: 84-82-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₇H₇N₅O₂

Molecular Weight: 193.16

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~10 mg/ml Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

MDL Number: MFCD00459812

PubChem CID: 66541

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/66541

SMILES: CN1C2=NC(=O)N(C(=O)C2=NC=N1)C

InChi: InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3

InChi Key: SLGRAIAQIAUZAQ-UHFFFAOYSA-N

Category: Biochemicals