PKR1 (F58) polyclonal Antibody | BS2957

PKR1 (F58) polyclonal Antibody | BS2957 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:1000 IF: 1:50~1:200

Background: The prokineticin receptors, PKR1 (GPR73a) and PKR2 (GPR73b), are G proteincoupled receptors responsible for mediating the signal transduction of both EG-VEGF and Prokineticin-2. PKR1 and PKR2 share 87% sequence identity. PKR1 is predominantly expressed in the peripheral tissues and PKR2 is typically expressed in the CNS. Both receptors are found in the testis. Upon ligand binding, PKR1 and PKR2 associate with G protein and can promote intracellular calcium mobilization, stimulate phosphoinositide turnover and activate the MAPK pathway. These receptors play a role in a variety of physiological events such as intestinal contraction, ingestive behavior, spermatogenesis, angiogenesis, circadian rhythm, neuronal survival and hyperalgesia. PKR1 may promote cardiomyocyte survival. PKR2 is essential for the normal development of the olfactory bulb. Mutations in the gene encoding PKR2 may result in Kallmann syndrome type 3.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PKR1 (F58) polyclonal Antibody detects endogenous levels of PKR1 protein.

Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Prokineticin receptor 1; PK-R1; G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a; PROKR1; GPR73; PKR1

Immunogen: Synthetic peptide, corresponding to amino acids 20-70 of Human PKR1.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A