PLA2G4F Antibody (Center) [AMR09322G]

PLA2G4F Antibody (Center) [AMR09322G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This PLA2G4F antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 289-331 amino acids from the Central region of human PLA2G4F.

Cellular Localisation: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q50L41}. Cell membrane {ECO:0000250|UniProtKB:Q50L41}; Peripheral membrane protein. Mitochondrion

Molecular Weight: 95082

Clone: Polyclonal

Gene Name: PLA2G4F

Gene ID: 255189

Function: Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:29158256) . Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:29158256) . Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:29158256) . In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (PubMed:29158256) .

Summary: Tissue Location: Expressed in myocardium (at protein level) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Cytosolic phospholipase A2 zeta, cPLA2-zeta, 3.1.1.4, Phospholipase A2 group IVF, PLA2G4F