PLAA Antibody (Center) [APR33498G]

PLAA Antibody (Center) [APR33498G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PLAA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 294-328 amino acids from the Central region of human PLAA.

Cellular Localisation: Nucleus. Cytoplasm. Cell junction, synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains

Molecular Weight: 87157

Clone: Polyclonal

Gene Name: PLAA

Gene ID: 9373

Function: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622) . Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity) . May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622) . Plays a role in cerebellar Purkinje cell development (By similarity) . Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha) - or lipopolysaccharide (LPS) -dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP