Pleiotrophin (PTN), human recombinant | 4469

Human Pleiotrophin (PTN) also called HARP (Heparin affin regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN (Pleiotrophin) and MK (midkine) are structural homologs, and are highly conserved among species. PTN plays an important role in development processes and promotion of neurite extension. Recombinant human PTN is a His-tag fusion protein (17.3 kDa) containing 136 amino acid residues of the PTN.

4469 | Pleiotrophin PTN human recombinant DataSheet

Biomolecule/Target: Pleiotrophin

Synonyms: PTN, Heparin Affin Regulatory Protein, HARP, Heparin-binding growth factor-8, HBGF-8, Osteoblast-Specific Factor-1, OSF-1, Heparin-binding growth-associated molecule, HB-GAM, HBNF-1 Heparin-binding brain mitogen, Heparin-binding neurite outgrowth-promoting factor 1, HBBM, NEGF1.

Alternates names: IL-1F8, IL-1H2, IL-1 eta, IL-1F8

Taglines: A heparin-binding growth factor

NCBI Gene ID #: 26525

NCBI Gene Symbol: IL36B

Gene Source: Human

Accession #: Q9UBH0

Recombinant: Yes

Source: E. coli.

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: < 0.1 ng/g of protein (<1EU/g).

Activity (Specifications/test method): Measured by its ability to induce IL-8 production by human PBMCs

Biological activity: Measured by its ability to induce IL-8 production by human PBMCs

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 17.3 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Amino acid sequence: MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE