Plinabulin | B2049

Plinabulin (NPI-2358) is a vascular disrupting agent (VDA). Plinabulin binds to the colchicine binding site of β-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. It is also an antineoplastic agent that activates an immune response. Plinabulin induces dendritic cell maturation and cytokines interleukin-1β (IL-1β), IL-6, and IL-12 production, all of which are important in neutrophil survival.

Plinabulin (NPI-2358) is a vascular disrupting agent (VDA). Plinabulin binds to the colchicine binding site of β-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. It is also an antineoplastic agent that activates an immune response. Plinabulin induces dendritic cell maturation and cytokines interleukin-1β (IL-1β), IL-6, and IL-12 production, all of which are important in neutrophil survival.

B2049 | Plinabulin DataSheet

Alternate Name/Synonyms: (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione; NPI-2358

Appearance: Yellow solid

Formulation: N/A

CAS Number: 714272-27-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₀N₄O₂

Molecular Weight: 336.39

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A vascular disrupting agent (VDA)

MDL Number: N/A

PubChem CID: 949641

SMILES: CC(C)(C)C1=C(N=CN1)C=C2C(=O)NC(=CC3=CC=CC=C3)C(=O)N2

InChi: InChI=1S/C19H20N4O2/c1-19(2,3)16-13(20-11-21-16)10-15-18(25)22-14(17(24)23-15)9-12-7-5-4-6-8-12/h4-11H,1-3H3,(H,20,21)(H,22,25)(H,23,24)/b14-9-,15-10-

InChi Key: NRCMCRRFYFGFX-TYPNBTCFSA-N