BW
PLSCR1 polyclonal Antibody | BS60203
- SKU:
- BW-BS60203
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- Usually ships in 5 working days
Description
PLSCR1 polyclonal Antibody | BS60203 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB: 1:500~1:1000
Background: The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PLSCR1 polyclonal Antibody detects endogenous levels of PLSCR1 protein.
Molecular Weight: ~ 40 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Phospholipid scramblase 1; PL scramblase 1; Ca (2+) -dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1b
Immunogen: A synthetic peptide corresponding to residues in Human PLSCR1.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: