Description
A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.
Plumbagin displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo
Alternate Name/Synonyms: 5-Hydroxy-2-methyl-1,4-naphthalenedione
Appearance: Orange red solid
Formulation: N/A
CAS Number: 481-42-5
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₁₁H₈O₃
Molecular Weight: 188.18
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~20 mg/ml) or EtOH (~10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent histone acetyltransferase (HAT) inhibitor
MDL Number: MFCD00001682
PubChem CID: 10205
SMILES: CC1=CC(=O)C2=C(C1=O)C=CC=C2O
InChi: InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
InChi Key: VCMMXZQDRFWYSE-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |