Plumbagin | 2290

A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.

Plumbagin displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo

2290 | Plumbagin DataSheet

Alternate Name/Synonyms: 5-Hydroxy-2-methyl-1,4-naphthalened­ione

Appearance: Orange red solid

Formulation: N/A

CAS Number: 481-42-5

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₁H₈O₃

Molecular Weight: 188.18

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~20 mg/ml) or EtOH (~10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent histone acetyltransferase (HAT) inhibitor

MDL Number: MFCD00001682

PubChem CID: 10205

SMILES: CC1=CC(=O)C2=C(C1=O)C=CC=C2O

InChi: InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3

InChi Key: VCMMXZQDRFWYSE-UHFFFAOYSA-N