Description
Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of Ras-GAP and ERK1 with Kd values of 98 and 212 nM, respectively.
Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of Ras-GAP and ERK1 with Kd values of 98 and 212 nM, respectively.
Alternate Name/Synonyms: N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo- 1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)- 3-(trifluoromethyl)benzamide; SC1
Appearance: White solid
Formulation: N/A
CAS Number: 839707-37-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₂₅F₃N₈O₂
Molecular Weight: 550.54
Cell-Permeable?: Yes
Purity: ≥97% by HPLC
Solubilities: DMSO (100 mM)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A regulator of mouse embryonic stem cell (ESC) self-renewal
MDL Number: MFCD20527253
PubChem CID: 12003241
SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CC(=NN5C)C
InChi: InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
InChi Key: NBZFRTJWEIHFPF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |