PLX-4032 | 2235

Cell-permeable. A potent, selective and ATP-competitive, inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. PLX-40432 selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation.

A potent, selective and ATP-competitive, inhibitor of BRAF(V600E) kinase with potential antineoplastic activity.

2235 | PLX-4032 DataSheet

Alternate Name/Synonyms: Vemurafenib; RG7204, RO5185426

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1029872-54-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₁₈ClF₂N₃O₃S

Molecular Weight: 489.92

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent, selective and ATP-competitive, inhibitor of BRAF(V600E) kinase

MDL Number: MFCD18074504

PubChem CID: 42611257

SMILES: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F

InChi: InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)

InChi Key: GPXBXXGIAQBQNI-UHFFFAOYSA-N