PND-1186 | 2823

PND-1186 is a potent FAK (Focal adhesion kinase) inhibitor (IC₅₀ = 1.5 nM) with potential antineoplastic activity. PND-1186 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt. This results in the reduction of the number of cancer stem cells (CSCs) and inhibits tumor cell migration, proliferation and survival.

PND-1186 is a potent FAK (Focal adhesion kinase) inhibitor (IC₅₀ = 1.5 nM) with potential antineoplastic activity. PND-1186 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt. This results in the reduction of the number of cancer stem cells (CSCs) and inhibits tumor cell migration, proliferation and survival.

2823 | PND-1186 DataSheet

Alternate Name/Synonyms: 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; VS-4718; SR-2516;PND 1186;PND1186;SR 2516;SR2516

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1061353-68-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₆F₃N₅O₃

Molecular Weight: 501.5

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent FAK (Focal adhesion kinase) inhibitor

MDL Number: N/A

PubChem CID: 25073775

SMILES: CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC

InChi: InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)

InChi Key: IGUBBWJDMLCRIK-UHFFFAOYSA-N