PNPLA2 Antibody (N-term) [APR10847G]

PNPLA2 Antibody (N-term) [APR10847G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PNPLA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-78 amino acids from the N-terminal region of human PNPLA2.

Cellular Localisation: Lipid droplet. Cell membrane; Single-pass type II membrane protein

Molecular Weight: 55316

Clone: Polyclonal

Gene Name: PNPLA2 (HGNC:30802)

Gene ID: 57104

Function: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674, PubMed:15364929, PubMed:16150821) . Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone (By similarity) . Also has acylglycerol transacylase activity. Acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity) . Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1, 3- diacylglycerol from triglycerides (PubMed:17603008) . Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926) . May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity) .

Summary: Tissue Location: Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Patatin-like phospholipase domain-containing protein 2, Adipose triglyceride lipase, Calcium-independent phospholipase A2, Desnutrin, IPLA2-zeta, Pigment epithelium-derived factor, TTS22, Transport-secretion protein 2, TTS2, PNPLA2, ATGL