Posaconazole | 9526

Posaconazole is a broad-spectrum, second-generation triazole compound that displays antifungal activity. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC₅₀s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.

Posaconazole is a broad-spectrum, second-generation triazole compound that displays antifungal activity. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC₅₀s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.

9526 | Posaconazole DataSheet

Alternate Name/Synonyms: 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; Noxafil

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 171228-49-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₇H₄₂F₂N₈O₄

Molecular Weight: 700.78

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO(0.5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An antifungal agent and lanosterol 14α-demethylase inhibitor

MDL Number: N/A

PubChem CID: 468595

SMILES: CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

InChi: CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

InChi Key: RAGOYPUPXAKGKH-XAKZXMRKSA-N