PP1 | 1927

Cell-permeable. A potent Src-selective tyrosine kinase (TK) inhibitor. Inhibits p56lck and p59fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also inhibits Kit and Bcr-Abl tyrosine kinases.

PP1 is a potent Src-selective tyrosine kinase (TK) inhibitor. Inhibits p56lck and p59fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also inhibits Kit and Bcr-Abl tyrosine kinases.

1927 | PP1 DataSheet

Alternate Name/Synonyms: 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Appearance: White solid

Formulation: N/A

CAS Number: 172889-26-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₉N₅

Molecular Weight: 281.36

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (25 mg/ml) or Ethanol (10 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent Src-selective tyrosine kinase (TK) inhibitor.

MDL Number: MFCD01076570

PubChem CID: 1400

SMILES: CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C

InChi: InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

InChi Key: ZVPDNRVYHLRXLX-UHFFFAOYSA-N