PPARA Antibody [AMR09449G]

PPARA Antibody [AMR09449G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M

Specificity: This PPARA antibody is generated from a mouse immunized with a recombination protein from the human region of human PPARA.

Cellular Localisation: Nucleus.

Molecular Weight: 52225

Clone: Monoclonal

Gene Name: PPARA

Gene ID: 5465

Function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC) . Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

Summary: Tissue Location: Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC, IF, IHC-P

Dilution: FC--1:25 IF--1:25 IHC-P--1:100~500 WB--1:1000

Synonyms: Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR