PPM1D Antibody (C-term) [APR32561G]

PPM1D Antibody (C-term) [APR32561G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-602 amino acids from the C-terminal region of human PPM1D.

Cellular Localisation: Nucleus. Cytoplasm, cytosol

Molecular Weight: 66675

Clone: Polyclonal

Gene Name: PPM1D

Gene ID: 8493

Function: Involved in the negative regulation of p53 expression (PubMed:23242139) . Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512) . Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629) . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity) .

Summary: Tissue Location: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1