PPM1D Polyclonal Antibody | E-AB-52172

PPM1D Polyclonal Antibody | E-AB-52172 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: EC 3.1.3.16, p53 induced protein phosphatase 1, p53-induced protein phosphatase 1, PP2C delta, PP2C-delta, PP2CD, Ppm1d, PPM1D, Protein phosphatase 1D, protein phosphatase 1D magnesium-dependent delta isoform , Protein phosphatase 2C delta isoform, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium dependent 1 delta, Protein phosphatase magnesium-dependent 1 delta, Protein phosphatase Mg2+/Mn2+ dependent 1D, Protein phosphatase Wip1, Wild type p53 induced phosphatase 1, WIP 1, WIP1

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Signal transduction

Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Concentration: 0.5 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human PPM1D

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:300, ELISA 1:2000-1:5000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A