PPP1R16B polyclonal Antibody | BS61720

PPP1R16B polyclonal Antibody | BS61720 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Protein phosphatase 1 regulatory inhibitor subunit 16B, regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956) . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873) . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity) . Protects the endothelial barrier from lipopolysaccharide (LPS) -induced vascular leakage (By similarity) . Involved in the regulation of endothelial cell filopodia extension (By similarity) . May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956) . Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956) . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087) . Involved in the dephosphorylation of EEF1A1 (PubMed:26497934) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PPP1R16B polyclonal Antibody detects endogenous levels of PPP1R16B protein.

Molecular Weight: ~ 63, 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Protein phosphatase 1 regulatory inhibitor subunit 16B; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP; PPP1R16B; ANKRD4; KIAA0823

Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human PPP1R16B.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: