PPP2R1A Antibody (C-term) [APR04462G]

PPP2R1A Antibody (C-term) [APR04462G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PPP2R1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-481 amino acids from the C-terminal region of human PPP2R1A.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:Q32PI5}. Nucleus. Chromosome, centromere. Lateral cell membrane. Cell projection, dendrite. Note=Centromeric localization requires the presence of BUB1.

Molecular Weight: 65309

Clone: Polyclonal

Gene Name: PPP2R1A

Gene ID: 5518

Function: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651) . Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Medium tumor antigen-associated 61 kDa protein, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, PPP2R1A