PPP6C Antibody (N-term) [AMM08668G]

PPP6C Antibody (N-term) [AMM08668G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPP6C.

Cellular Localisation: Mitochondrion. Cytoplasm

Molecular Weight: 35144

Clone: Polyclonal

Gene Name: PPP6C

Gene ID: 5537

Function: Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956) . PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379) . N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194) . During mitosis, regulates spindle positioning (PubMed:27335426) . Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228) . Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG- I/DDX58-mediated signaling activation (PubMed:29053956) .

Summary: Tissue Location: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: IHC-P--1:100~500 WB--1:1000

Synonyms: Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6