Prasugrel | 9472

Prasugrel is novel thienopyridine antiplatelet prodrug that is metabolized to the thiol-containing active metabolite R-138727,which binds to and irreversibly inhibits the platelet P2Y12ADP receptor. Prasugrel is metabolized by the liver- and intestinal-dominant carboxylesterases CE1 and CE2 to give a mixture of four enantiomers that inhibit platelet aggregation.

Prasugrel is novel thienopyridine antiplatelet prodrug that is metabolized to the thiol-containing active metabolite R-138727,which binds to and irreversibly inhibits the platelet P2Y12ADP receptor. Prasugrel is metabolized by the liver- and intestinal-dominant carboxylesterases CE1 and CE2 to give a mixture of four enantiomers that inhibit platelet aggregation.

9472 | Prasugrel DataSheet

Alternate Name/Synonyms: 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone; CS-747, LY640315

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 150322-43-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₀FNO₃S

Molecular Weight: 373.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml on warming)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An antiplatelet prodrug

MDL Number: MFCD09954140

PubChem CID: 6918456

SMILES: CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4

InChi: InChI=1S/C20H20FNO3S/c1-12(23)25-18-10-14-11-22(9-8-17(14)26-18)19(20(24)13-6-7-13)15-4-2-3-5-16(15)21/h2-5,10,13,19H,6-9,11H2,1H3

InChi Key: DTGLZDAWLRGWQN-UHFFFAOYSA-N