Pravastatin sodium | B2727

Pravastatin is a HMG-CoA (Hydroxymethylglutaryl-coenzyme A reductase) inhibitor that is a ring hydroxylated metabolite of mevastatin (Cat. No. 1694). It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule. Pravastatin is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.

Pravastatin is a HMG-CoA (Hydroxymethylglutaryl-coenzyme A reductase) inhibitor that is a ring hydroxylated metabolite of mevastatin (Cat. No. 1694). It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule. Pravastatin is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.

B2727 | Pravastatin sodium DataSheet

Alternate Name/Synonyms: 1S,2S,6S,7S,8R,8aR-hexahydro-βR,δR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid, monosodium salt

Appearance: White solid

Formulation:

CAS Number: 81131-70-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₃₅O₇ • Na

Molecular Weight: 446.51

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A HMG-CoA reductase inhibitor t

MDL Number: MFCD00887601

PubChem CID: 16759173

SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)O.[Na+]

InChi: InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1

InChi Key: VWBQYTRBTXKKOG-IYNICTALSA-M