PRDM5 (PFM2) Antibody [APR30890G]

PRDM5 (PFM2) Antibody [APR30890G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PRDM5 (PFM2) antibody is generated from rabbits immunized with purified recombinant GST fusion protein encoding the N-terminal region of human PRDM5.

Cellular Localisation: Nucleus

Molecular Weight: 73090

Clone: Polyclonal

Gene Name: PRDM5

Gene ID: 11107

Function: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

Summary: Tissue Location: Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: N/A

Dilution: N/A

Synonyms: PR domain zinc finger protein 5, 211-, PR domain-containing protein 5, PRDM5, PFM2