Prekallikrein, Human Plasma | 7685

Prekallikrein is the glycosylated single chain zymogen precursor of the plasma serine protease kallikrein. Plasma prekallikrein circulates with kininogen and is activated by Factor XIIa in the intrinsic coagulation pathway. Kallikrein activates plasminogen in fibrinolysis and cleaves kininogen in the bradykinin system of vasodilation. Prekallikrein deficiency is rare and causes increased activated partial thromboplastin time. Elevated plasma prekallikrein is associated with diabetes and cardiovascular disease.

7685 | Prekallikrein Human Plasma DataSheet

Biomolecule/Target: Prekallikrein

Synonyms: Fletcher factor, Kininogenin.

Alternates names: Fletcher factor, Kininogenin.

Taglines: Activates plasminogen in fibrinolysis and cleaves kininogen in the bradykinin system of vasodilation.

NCBI Gene ID #: 8600

NCBI Gene Symbol: OPGL

Gene Source: Human

Accession #: O14788

Recombinant: No

Source: Human Plasma

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: The ED as determined by the dose-dependent stimulation of IL-8 production by human PBMC is <10 ng/ml.

Results: Lot dependent

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 86 kDa

Concentration: N/A

Appearance: Liquid

Physical form description: In 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg /ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A