PREPL Antibody (C-term) [APR05656G]

PREPL Antibody (C-term) [APR05656G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, Ha, M

Specificity: This PREPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-652 amino acids from the C-terminal region of human PREPL.

Cellular Localisation: Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8C167}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C167}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C167}. Nucleus Note=Co-localizes with AP-1 in the trans-Golgi network (By similarity) Co-localizes with MAP2 and ACTB on the cytoskeleton (By similarity) Co-localizes with STX6 and GOSR2 at the Golgi apparatus (By similarity) . {ECO:0000250|UniProtKB:Q8C167}

Molecular Weight: 83927

Clone: Polyclonal

Gene Name: PREPL

Gene ID: 9581

Function: Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805) . Does not cleave peptides after a arginine or lysine residue (PubMed:16143824) . Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636) . May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330) .

Summary: Tissue Location: Expressed in pyramidal neurons of the temporal cortex and neocortex (at protein level) (PubMed:23485813) . Widely expressed (PubMed:15913950, PubMed:16385448) . Expressed at higher level in brain, skeletal muscle, heart and kidney (PubMed:15913950, PubMed:16385448) . Expressed at the endplates in the neuromuscular junction (PubMed:24610330) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Prolyl endopeptidase-like, 3421-, Prolylendopeptidase-like, PREPL, KIAA0436