Pridopidine | B3045

Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is 100-fold higher than the affinity for D2 Receptor (high-affinity Ki of 70 nM at S1R and 7520 nM at D2 receptor). It improves motor function and shows neuroprotective effects in Huntington Disease mouse model. Due to interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors, modulators of sigma receptors are being investigated for the treatment of SARS-Cov-2.

Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is 100-fold higher than the affinity for D2 Receptor (high-affinity Ki of 70 nM at S1R and 7520 nM at D2 receptor). It improves motor function and shows neuroprotective effects in Huntington Disease mouse model. Due to interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors, modulators of sigma receptors are being investigated for the treatment of SARS-Cov-2.

B3045 | Pridopidine DataSheet

Alternate Name/Synonyms: 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine; 4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine; ACR16; Huntexil

Appearance: White Solid

Formulation:

CAS Number: 346688-38-8

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₅H₂₃NO₂S

Molecular Weight: 281.41

Cell-Permeable?: FALSE

Purity: ≥97%

Solubilities: Soluble in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist

MDL Number: MFCD09835586

PubChem CID: 9795739

SMILES: CCCN1CCC(CC1)C2=CC(=CC=C2)S(=O)(=O)C

InChi: InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3

InChi Key: YGKUEOZJFIXDGI-UHFFFAOYSA-N