Pritelivir mesylate | B2154

Pritelivir is a potent helicase primase inhibitor. It inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of Pritelivir in vivo was found to be superior compared to all compounds currently used to treat HSV infections.

Pritelivir is a potent helicase primase inhibitor. It inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of Pritelivir in vivo was found to be superior compared to all compounds currently used to treat HSV infections.

B2154 | Pritelivir mesylate DataSheet

Alternate Name/Synonyms: N-methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide mesylate; BAY 57-1293

Appearance: White solid

Formulation: N/A

CAS Number: 1428333-96-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₂N₄O₆S₃

Molecular Weight: 498.59

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent helicase primase inhibitor

MDL Number: N/A

PubChem CID: 491941

SMILES: CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N

InChi: InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)

InChi Key: IVZKZONQVYTCKC-UHFFFAOYSA-N