PRMT1 polyclonal Antibody | BS91107

PRMT1 polyclonal Antibody | BS91107 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC CHIP

Application Range: WB:1:500-1:1,000 ICC:1:100-1:500 IHC:1:50-1:200

Background: A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMT1, the predominant form in mammalian cells, is located in the nucleus, while PRMT3 is present in the cytoplasm. At the carboxy-terminus, interleukin enhancer-binding factor 3 (ILF3) binds PRMT1, thereby regulating PRMT1 activitiy. Alternative mRNA splicing of the PRMT gene results in three isoforms of PRMT1 that differ in their amino-terminus regions. All three splice variants of PRMT1 are enzymatically active. PRMT3 recognizes and binds to RNA-associated substrates with a zinc-finger domain in its amino-terminus. The zinc-liganded form of this domain is required for the enzyme to recognize RNA-associated substrates.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PRMT1 polyclonal Antibody detects endogenous levels of PRMT1 protein.

Molecular Weight: 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PRMT1, ANM 1, ANM1, ANM1, HCP 1, HCP1, Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2, Heterogeneous nuclear ribonucleoproteins methyltransferase like2, Histone-arginine N-methyltransferase PRMT1, HMT 2, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2, HMT1 hnRNP methyltransferase, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae), HMT1 hnRNP methyltransferase like 2, HMT2, HRMT1 L2, HRMT1L 2, HRMT1L2, Human mRNA for suppressor for yeast mutant, Human mRNA for suppressor for yeast mutant complete cds, Interferon receptor 1 bound protein 4, Interferon receptor 1 bound protein4, Interferon receptor 1-bound protein 4, Interferon receptor 1bound protein 4, IR1 B4, IR1B 4, IR1B4, Mrmt 1, Mrmt1, PRMT 1, PRMT1, Protein arginine methyltransferase 1, Protein arginine N methyltransferase 1, Protein arginine N methyltransferase1, Protein arginine N-methyltransferase 1, R1B4, S. cerevisiae like 2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: