PRMT4/CARM1 Inhibitor | B2808

PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM. In human prostate adenocarcinoma cancer LNCaP cells, PRMT4/CARM1 inhibitor showed a significant dose-dependent reduction of the prostate-specific antigen promoter activity, at concentrations that did not affect cell viability.

PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM. In human prostate adenocarcinoma cancer LNCaP cells, PRMT4/CARM1 inhibitor showed a significant dose-dependent reduction of the prostate-specific antigen promoter activity, at concentrations that did not affect cell viability.

B2808 | PRMT4/CARM1 Inhibitor DataSheet

Alternate Name/Synonyms: Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, (3E,5E)-1-benzyl-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]piperidin-4-one, CARM1-IN-1

Appearance: Crystalline solid

Formulation:

CAS Number: 1020399-49-8

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₆H₂₁Br₂NO₃

Molecular Weight: 555.26

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~35 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1

MDL Number:

PubChem CID: 24827559

SMILES: C1C(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)CN1CC4=CC=CC=C4

InChi: InChI=1S/C26H21Br2NO3/c27-22-12-18(6-8-24(22)30)10-20-15-29(14-17-4-2-1-3-5-17)16-21(26(20)32)11-19-7-9-25(31)23(28)13-19/h1-13,30-31H,14-16H2/b20-10+,21-11+

InChi Key: KNMFTTWVELIVCC-CLVAPQHMSA-N