Description
PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM. In human prostate adenocarcinoma cancer LNCaP cells, PRMT4/CARM1 inhibitor showed a significant dose-dependent reduction of the prostate-specific antigen promoter activity, at concentrations that did not affect cell viability.
PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM. In human prostate adenocarcinoma cancer LNCaP cells, PRMT4/CARM1 inhibitor showed a significant dose-dependent reduction of the prostate-specific antigen promoter activity, at concentrations that did not affect cell viability.
B2808 | PRMT4/CARM1 Inhibitor DataSheet
Alternate Name/Synonyms: Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, (3E,5E)-1-benzyl-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]piperidin-4-one, CARM1-IN-1
Appearance: Crystalline solid
Formulation:
CAS Number: 1020399-49-8
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₂₆H₂₁Br₂NO₃
Molecular Weight: 555.26
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~35 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1
MDL Number:
PubChem CID: 24827559
SMILES: C1C(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)CN1CC4=CC=CC=C4
InChi: InChI=1S/C26H21Br2NO3/c27-22-12-18(6-8-24(22)30)10-20-15-29(14-17-4-2-1-3-5-17)16-21(26(20)32)11-19-7-9-25(31)23(28)13-19/h1-13,30-31H,14-16H2/b20-10+,21-11+
InChi Key: KNMFTTWVELIVCC-CLVAPQHMSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |