Probucol | B2968

Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. The use of probucol is limited, because it leads to the reduction of HDL cholesterol. Probucol inhibits cholesterol efflux up to 80% in J774 macrophages expressing ATP-binding cassette transporter A1 (ABCA1) by inhibiting ABCA1 translocation to the plasma membrane. Administration of probucol at 3.5 mg/kg/day for 2 months increases the activity of glutathione peroxidase in an in vivo mouse model of Huntington’s disease and is protective against behavioral and striatal oxidative damage.

Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions. The use of probucol is limited, because it leads to the reduction of HDL cholesterol. Probucol inhibits cholesterol efflux up to 80% in J774 macrophages expressing ATP-binding cassette transporter A1 (ABCA1) by inhibiting ABCA1 translocation to the plasma membrane. Administration of probucol at 3.5 mg/kg/day for 2 months increases the activity of glutathione peroxidase in an in vivo mouse model of Huntington’s disease and is protective against behavioral and striatal oxidative damage.

B2968 | Probucol DataSheet

Alternate Name/Synonyms: 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol; Lorelco; Biphenabid; Bisphenabid; NSC 86225; NSC 652160; DH 581; 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol)

Appearance: Solid

Formulation:

CAS Number: 23288-49-5

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₃₁H₄₈O₂S₂

Molecular Weight: 516.84

Cell-Permeable?: True

Purity: >98.0%

Solubilities: ~25 mg/ml in in Ethanol, ~30 mg/ml in DMF in 0, ~20 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antioxidant and anti-hyperlipidemic drug

MDL Number: MFCD00079281

PubChem CID: 4912

SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C

InChi: InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

InChi Key: FYPMFJGVHOHGLL-UHFFFAOYSA-N