Procathepsin K Antibody | 6661

Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of Procathepsin K to mature Cathepsin K is autocatalytic.

6661 | Procathepsin K Antibody DataSheet

Antibody Target: Procathepsin K

Target Alternative Name: CTSK, CTSO, CTSO3

Tag Line: Polyclonal Antibody to detect Procathepsin K in rat samples

Category: Procathepsin K

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Rat

Immunogen Sequence: Recombinant rat Procathepsin K (Cat # 1029)

Accession #: P00786

Gene ID: 25425

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.

Purification: Affinity Purified Antibody

Application: Western blot

Positive Control: Western Blot: Recombinant protein

Application And Usages: Western blot: 1-4 µg/ml.

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified:

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified