Profilin 1 polyclonal Antibody | BS91111

Profilin 1 polyclonal Antibody | BS91111 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse,Rat

Application: WB ICC IHC FC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: Profilins regulate Actin polymerization by binding to and sequestering the Actin monomer. Profilins act as a nucleotide exchange factor that charges Actin with ATP after binding the Actin monomer through a 1:1 stoichiometric relationship. Human Profilin-1 and Profilin-2 are encoded by two separate genes mapping to chromosomes 17p13.2 and 3q25.1, respectively. Both Profilin-1 and Profilin-2 are abundantly expressed in kidney. Profilin-1 is highly expressed in lung, liver, placenta and kidney while Profilin-2 is highly expressed in brain and skeletal muscle. In axonal and dendritic processes of mouse brain, Profilins co-localize with dynamin I and synapsin. Profilin may play a role in mediating cell adhesion. The overexpression of Profilin in endothelial cells results in increased adhesion to Fibronectin. In food allergy, plant Profilin is considered a pan-allergen. Case studies indicate individuals with allergies to various foods including celery, carrots, zucchini and peanuts are actually sensitive to the Profilin proteins in these foods.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Profilin 1 polyclonal Antibody detects endogenous levels of Profilin 1 protein.

Molecular Weight: 15 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PFN1, Actin binding protein, ALS18, Epididymis tissue protein Li 184a, OTTHUMP00000125244, PFN 1, Pfn, PFN1, PROF1, Profilin I, Profilin-1, Profilin1, ProfilinI,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: