BW
Progesterone Receptor polyclonal Antibody | BS91113
- SKU:
- BW-BS91113
- Availability:
- Usually ships in 5 working days
Description
Progesterone Receptor polyclonal Antibody | BS91113 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC FC
Application Range: WB:1:500-1:1,000 ICC:1:200-1:800 FC:1:50-1:100
Background: The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single copy of the PR gene. The first 164 amino acids of PR-B are absent in PR-A. Progesterone-bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms. Interestingly, the ID is functionally active only in PR-A and is necessary for steroid hormone transrepression by PR-A, suggesting that PR-A and PR-B may have different conformations in the cell.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Progesterone Receptor polyclonal Antibody detects endogenous levels of Progesterone Receptor protein.
Molecular Weight: 99/82 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PR, PGR, NR3C3, NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, PRGR, Progesterone receptor, Progestin receptor form A, Progestin receptor form B,
Immunogen: Peptide
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Peptide affinity purified
Pathway: