Prostaglandin E2 | 2268

Prostaglandin E2 (PGE2) is a primary product of arachidonic metabolism and is synthesized via the cyclooxygenase (COX) and prostaglandin synthase pathways. PGE2 production is a commonly used method for the detection of COX-1 and COX-2 modulation and prostaglandin synthases. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. Regulates vertebrate haematopoietic stem cell homeostasis.

Prostaglandin E2 (PGE2) is a primary product of arachidonic metabolism and is synthesized via the cyclooxygenase (COX) and prostaglandin synthase pathways. Regulates vertebrate haematopoietic stem cell homeostasis.

2268 | Prostaglandin E2 DataSheet

Alternate Name/Synonyms: 9-​Oxo-​11α,​15S-​dihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid; PGE2; Dinoprostone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 363-24-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₃₂O₅

Molecular Weight: 352.47

Cell-Permeable?: No

Purity: ≥98% by TLC

Solubilities: DMSO (~100 mg/ml) or EtOH (~100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An endogenous prostanoid

MDL Number: MFCD00077861

PubChem CID: 5280360

SMILES: CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O

InChi: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1

InChi Key: XEYBRNLFEZDVAW-ARSRFYASSA-N