Prostate-Specific Membrane Antigen Antibody (PSMA)| F43183-0.08ML

Prostate-Specific Membrane Antigen Antibody (PSMA)| F43183-0.08ML | Gentaur UK, US & Europe Distribution

Background: GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA). Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All of which refer to the same protein, glutamate carboxypeptidase II. PSMA is strongly expressed in the human prostate, being a hundredfold greater than the expression in most other tissues. In cancer, it is upregulated in expression and has been called the second-most-upregulated gene in prostate cancer, with increase of 8- to 12-fold over the noncancerous prostate. In human prostate cancer, the higher expressing tumors are associated with quicker time to progression and a greater percentage of patients suffering relapse. [Wiki]

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Pig

Application: IF, WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:10-1:50, Immunofluorescence: 1:10-1:50

Application Note: Titration of the PSMA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This PSMA antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 161-190 from the human protein was used as the immunogen for this PSMA antibody.

Storage: Aliquot the PSMA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A