PRP19 polyclonal Antibody | BS91118

PRP19 polyclonal Antibody | BS91118 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC FC

Application Range: WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The spliceosome, the 0gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules (U1, U2, U4, U5 and U6) . Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The PRP19-associated complex is required for stable association of U5 and U6 with the spliceosome after U4 is released. Changes within the spliceosome upon binding of the PRP19-associated complex include remodeling of the U6/5' splice site interaction and destabilization of Lsm proteins to allow further interaction of U6 with the intron sequence.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PRP19 polyclonal Antibody detects endogenous levels of PRP19 protein.

Molecular Weight: 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hPso4, PRPF19, hPso4, NMP200, Nuclear matrix protein 200, Nuclear matrix protein NMP200 related to splicing factor PRP19, pre mRNA processing factor 19, Pre-mRNA-processing factor 19, PRP19, PRP19/PSO4 homolog, PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae), PRP19, PRPF19, PSO4, psoralen 4, Senescence evasion factor, SNEV, UBOX4,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: