LBD
PRPF8 Antibody (C-term) [APR12995G]
- SKU:
- LBD-APR12995G
- Availability:
- Usually ships in 5 working days
Description
PRPF8 Antibody (C-term) [APR12995G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PRPF8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2239-2273 amino acids from the C-terminal region of human PRPF8.
Cellular Localisation: Nucleus. Nucleus speckle
Molecular Weight: 273600
Clone: Polyclonal
Gene Name: PRPF8
Gene ID: 10594
Function: Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome (PubMed:10411133, PubMed:11971955, PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154) . Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Summary: Tissue Location: Widely expressed..
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Pre-mRNA-processing-splicing factor 8, 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220, PRPF8, PRPC8