BW
PRTN3 polyclonal Antibody | BS91120
- SKU:
- BW-BS91120
- Availability:
- Usually ships in 5 working days
Description
PRTN3 polyclonal Antibody | BS91120 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Application: WB ICC IHC
Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:100-1:500
Background: The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PRTN3 polyclonal Antibody detects endogenous levels of PRTN3 protein.
Molecular Weight: 27 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: PR-3, PR3, NP-4, PRTN3, MBN, ACPA, AGP 7, AGP7, AGP7 serine proteinase, Azurophil Granule Protein 7, C ANCA, C ANCA antigen, C-ANCA antigen, CANCA, EC 3.4.21.76, Leukocyte proteinase 3, MBN, MBT, MBT WEGENER AUTOANTIGEN, Myeloblastin, Neutrophil proteinase 4, NP 4, NP-4, NP4, P29, PR 3, PR-3, PR3, Proteinase 3, Proteinase3, PRTN 3, Prtn3, PRTN3, Serine proteinase neutrophil Wegener granulomatosis autoantigen, Serine proteinase, neutrophil, Wegener autoantigen, Wegener granulomatosis autoantigen,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: