PSCA Antibody (Center) [AMM08670G]

PSCA Antibody (Center) [AMM08670G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This PSCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human PSCA.

Cellular Localisation: Cell membrane; Lipid-anchor, GPI-anchor

Molecular Weight: 11959

Clone: Polyclonal

Gene Name: PSCA

Gene ID: 8000

Function: May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.

Summary: Tissue Location: Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells) . Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts) Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level) . Not detected in normal intestinal epithelium (at protein level) . Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000-1:2000

Synonyms: Prostate stem cell antigen, PSCA