PT-2385 | B1920

PT-2385 is a potent ad selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very effective in blocking cancer cell growth, proliferation, and tumor angiogenesis characteristic in clear cell renal cell carcinoma (ccRCC).

PT-2385 is a potent ad selective inhibitor of hypoxia inducible factor (HIF-2α) with potential antineoplastic activity. PT-2385 selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Very effective in blocking cancer cell growth, proliferation, and tumor angiogenesis characteristic in clear cell renal cell carcinoma (ccRCC).

B1920 | PT-2385 DataSheet

Alternate Name/Synonyms: (S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile; PT2385

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1672665-49-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₂F₃NO₄S

Molecular Weight: 383.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ad selective inhibitor of hypoxia inducible factor (HIF-2α)

MDL Number: N/A

PubChem CID: 91754484

SMILES: CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)(F)F)O

InChi: InChI=1S/C17H12F3NO4S/c1-26(23,24)14-3-2-13(12-7-17(19,20)16(22)15(12)14)25-11-5-9(8-21)4-10(18)6-11/h2-6,16,22H,7H2,1H3/t16-/m0/s1

InChi Key: ONBSHRSJOPSEGS-INIZCTEOSA-N