PTBP1 monoclonal Antibody | MB9458

PTBP1 monoclonal Antibody | MB9458 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Rat

Application: WB IHC ICC FC

Application Range: WB:1:5,000-1:10,000 IHC:1:50-1:100 ICC:1:50-1:100 FC:1:50-1:100

Background: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: PTBP1 monoclonal Antibody detects endogenous levels of PTBP1 protein.

Molecular Weight: 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PTB, hnRNP I, PTBP1, PTB, 57 kDa RNA binding protein PPTB 1, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, Heterogeneous Nuclear Ribonucleoprotein Polypeptide I, hnRNP I, HNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), Polypyrimidine Tract Binding Protein 1, Polypyrimidine tract binding protein, Polypyrimidine tract-binding protein 1, pPTB, PTB 1, PTB 2, PTB 3, PTB 4, PTB, PTB T, PTB1, PTB2, PTB3, PTB4, PTBP 1, PTBP1, PTBP1, PTBT, RNA Binding Protein,

Immunogen: Recombinant protein within human PTBP1 aa 320-550.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProG affinity purified.

Pathway: