PTC-209 | B1055

PTC-209 is a potent, cell-permeable, BMI-1 inhibitor (IC₅₀ = 0.5 µM) with potential anticancer activity. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs). PTC-209 inhibits tumor growth, and reduces the levels of CICs present in colon cancer tumor xenografts in mice.

PTC-209 is a potent, cell-permeable, BMI-1 inhibitor (IC₅₀ = 0.5 µM) with potential anticancer activity. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs). PTC-209 inhibits tumor growth, and reduces the levels of CICs present in colon cancer tumor xenografts in mice.

B1055 | PTC-209 DataSheet

Alternate Name/Synonyms: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 315704-66-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₃Br₂N₅OS

Molecular Weight: 495.19

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, cell-permeable, BMI-1 inhibitor

MDL Number: MFCD02110649

PubChem CID: 1117196

SMILES: CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br

InChi: InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H,1-2H3,(H,22,23)

InChi Key: XVOOCQSWCCRVDY-UHFFFAOYSA-N