PTGER3 Antibody (N-term) [APR32655G]

PTGER3 Antibody (N-term) [APR32655G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This PTGER3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human PTGER3.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 43310

Clone: Polyclonal

Gene Name: PTGER3

Gene ID: 5733

Function: Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210) . The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G (i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210) . Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS) . Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3 (-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid- induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity) .

Summary: Tissue Location: Detected in kidney (PubMed:8117308, PubMed:8135729) . Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:500

Synonyms: Prostaglandin E2 receptor EP3 subtype, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, PGE2-R, Prostanoid EP3 receptor, PTGER3