PTGR1 Antibody (Center) [APR32218G]

PTGR1 Antibody (Center) [APR32218G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This PTGR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-205 amino acids from the Central region of human PTGR1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:Q29073}.

Molecular Weight: 35870

Clone: Polyclonal

Gene Name: PTGR1

Gene ID: 22949

Function: NAD (P) H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (PubMed:25619643) . Catalyzes with high efficiency the reduction of the 13, 14 double bond of 15- oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15- oxo-PGF2-alpha (PubMed:25619643) . Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (PubMed:25619643) (By similarity) . Reduces 15-oxo-LXA4 to 13, 14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity) . May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha, beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E) -decenal and (3E) -3-nonen-2-one (PubMed:25619643) . May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity) .

Summary: Tissue Location: High expression in the kidney, liver, and intestine but not in leukocytes.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Prostaglandin reductase 1, PRG-1, 131-, 15-oxoprostaglandin 13-reductase, NADP-dependent leukotriene B4 12-hydroxydehydrogenase, PTGR1, LTB4DH