PTN polyclonal Antibody | BS7504

PTN polyclonal Antibody | BS7504 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200

Background: Pleiotrophin? (PTN) also known as?heparin-binding brain mitogen? (HBBM) or?heparin-binding growth factor 8? (HBGF-8) or?neurite growth-promoting factor 1? (NEGF1) or?heparin affinity regulatory peptide? (HARP) or?heparin binding growth associated molecule? (HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PTN polyclonal Antibody detects endogenous levels of PTN protein.

Molecular Weight: ~19 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HARP; HB-GAM; HBBM; HBGAM; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; heparin affin regulatory protein; Heparin binding growth associated molecule; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; Heparin-binding brain mitogen; heparin-binding growth associated molecule; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neurite outgrowth-promoting factor 1; NEGF1; Neurite Growth Promoting Factor 1; Neurite outgrowth-promoting factor, heparin-binding; OSF-1; OSF1; Osteoblast-specific factor 1; osteoblast-specific factor; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) ; Pleiotrophin; PTN; PTN_HUMAN;

Immunogen: Recombinant full length Human PTN.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: